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95% CI, 1.21-1.53) when compared with SGLT2 inhibitors, which was driven by an increase in the risk for GI motility-related outcomes, the researchers wrote

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Safety Advantage of Metformin & GLP-RA Combination: Is there a Mechanistic Basis

[2] [3] The most frequently documented adverse effects of tirzepatide include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and decreased appetite, which occur in a significant proportion of patients, particularly during dose escalation

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